| 6-55 | PR Stirling | Ireland v Afghanistan | Greater Noida Sports Complex Ground, Greater Noida | 2016/17 |
| 5-14 | DT Johnston | Ireland v Canada | Centurion Park, Centurion | 2008/09 |
| 5-20 | AR Cusack | Ireland v Afghanistan | Hazelaarweg, Rotterdam | 2010 |
| 5-46 | CA Young | Ireland v Scotland | The Village, Malahide, Dublin | 2014 |
| 5-46 | BJ McCarthy | Ireland v Afghanistan | Sharjah Cricket Association Stadium, Sharjah | 2017/18 |
| 5-49 | A van der Merwe | Ireland v Canada | Armour Heights, Toronto | 2010 |
| 4-11 | PR Stirling | Ireland v Netherlands | VRA Ground, Amstelveen | 2010 |
| 4-13 | KJ O'Brien | Ireland v Netherlands | VRA Ground, Amstelveen | 2013 |
| 4-15 | WB Rankin | Ireland v United Arab Emirates | Old Hararians, Harare | 2017/18 |
| 4-19 | AC Botha | Ireland v Kenya | Civil Service Cricket Club, Stormont, Belfast | 2008 |
| 4-24 | GH Dockrell | Ireland v Scotland | Civil Service Cricket Club, Stormont, Belfast | 2013 |
| 4-26 | DT Johnston | Ireland v England | Civil Service Cricket Club, Stormont, Belfast | 2009 |
| 4-26 | RM West | Ireland v Scotland | Mannofield Park, Aberdeen | 2009 |
| 4-26 | KJ O'Brien | Ireland v Afghanistan | Greater Noida Sports Complex Ground, Greater Noida | 2016/17 |
| 4-27 | JF Mooney | Ireland v Canada | Castle Avenue, Dublin | 2011 |
| 4-28 | GH Dockrell | Ireland v Afghanistan | Sharjah Cricket Association Stadium, Sharjah | 2017/18 |
| 4-30 | WK McCallan | Ireland v Kenya | Castle Avenue, Dublin | 2009 |
| 4-32 | AR Cusack | Ireland v Zimbabwe | Blundstone Arena, Hobart | 2014/15 |
| 4-32 | TJ Murtagh | Ireland v Zimbabwe | Harare Sports Club, Harare | 2015/16 |
| 4-35 | GH Dockrell | Ireland v Netherlands | VRA Ground, Amstelveen | 2010 |
| 4-35 | GH Dockrell | Ireland v Afghanistan | Dubai Sports City Stadium, Dubai | 2014/15 |
| 4-36 | WK McCallan | Ireland v Kenya | Ruaraka Sports Club Ground, Nairobi | 2006/07 |
| 4-40 | MC Sorensen | Ireland v Scotland | The Village, Malahide, Dublin | 2014 |
| 4-41 | TJ Murtagh | Ireland v West Indies | Harare Sports Club, Harare | 2017/18 |
| 4-41 | KJ O'Brien | Ireland v United Arab Emirates | ICC Cricket Academy Ground, Dubai | 2017/18 |
| 4-42 | AC Botha | Ireland v Kenya | Ruaraka Sports Club Ground, Nairobi | 2006/07 |
| 4-44 | AR White | Ireland v Netherlands | Castle Avenue, Dublin | 2010 |
| 4-44 | WB Rankin | Ireland v Afghanistan | Sharjah Cricket Association Stadium, Sharjah | 2017/18 |
| 4-45 | KJ O'Brien | Ireland v Afghanistan | Civil Service Cricket Club, Stormont, Belfast | 2016 |
| 4-59 | BJ McCarthy | Ireland v Afghanistan | Civil Service Cricket Club, Stormont, Belfast | 2016 |
| 4-62 | BJ McCarthy | Ireland v Pakistan | The Village, Malahide, Dublin | 2016 |
| 4-63 | JF Mooney | Ireland v England | M Chinnaswamy Stadium, Bangalore | 2010/11 |
| 4-63 | WB Rankin | Ireland v Scotland | Harare Sports Club, Harare | 2017/18 |
| 4-71 | KJ O'Brien | Ireland v West Indies | Punjab Cricket Association Stadium, Mohali | 2010/11 |